Solid Science & Technology
How does Solid work?
If you’re not injecting your nutrition and supplementation beneath the skin, you’re probably taking them through the mouth. But how does it get where it needs to go so your body can put it to work?
When you swallow other supplements, they have to travel through your intestines, stomach, and liver — a process that can filter out up to 90% of those nutrients. That means you’re lucky if your body absorbs 10% of the supplements you take!
Solid nutrients utilize intra-oral absorption, which means they get from the mouth to the bloodstream in less time than it took you to read this sentence. With Solid, you can absorb as much as 10X the amount of nutrients as with other options, and — because intra-oral absorption bypasses the gastrointestinal tract — your body can start using those nutrients right away.
More good news? Now you can skip added sugars, calories, water weight, ineffective absorption, wasted wait time, and the mess of traditional goos, gummies, energy drinks and powder mixes.
What is intra-oral absorption?
Intra-oral absorption is the world’s fastest, most convenient, and most effective supplement-delivery method, proven repeatedly in independent, third-party studies.
Our bodies can absorb nutrients — instantly and directly into the bloodstream — through the lining of the mouth (buccal tissue, oral mucosa and sublingual capillaries), but other products have to rely on the long, slow, and exclusionary process of the GI tract, where they undergo a process known as hepatic first-pass metabolism, which filters out and eliminates from your system up to 90% of what you were looking for.
What is Nutrient Density Technology?
Solid supplements use our own proprietary (no one else has it) patent-pending (no one can get it) Nutrient Density Technology (NDT) to harness the power of intra-oral absorption for maximum nutrition intake and effectiveness. This innovation also means Solid uses no fillers, binders or sugars, making it the fastest, most effective and nutrient-dense supplement delivery the world has seen.
CLINICAL STUDIES & SCIENTIFIC REVIEWS
Intra-oral delivery
"The oral mucosa has a thin epithelium and rich vascularity, which favor absorption; however, contact is usually too brief for substantial absorption. A drug placed between the gums and cheek (buccal administration) or under the tongue (sublingual administration) is retained longer, enhancing absorption."
https://www.merckmanuals.com/professional/clinical-pharmacology/pharmacokinetics/drug-absorption
"Oral mucosal drug delivery is an alternative method of systemic drug delivery that offers several advantages over both injectable and enteral methods. Because the oral mucosa is highly vascularized, drugs that are absorbed through the oral mucosa directly enter the systemic circulation, bypassing the gastrointestinal tract and first-pass metabolism in the liver."
https://www.ncbi.nlm.nih.gov/pubmed/12126458
"Sublingual or buccal forms of drugs have their advantages. The cheek and area under the tongue have many capillaries, or tiny blood vessels. There, drugs can be absorbed directly into the bloodstream without going through your digestive system. Further, these drugs do not go through the digestive system, so they aren’t metabolized through your liver. This means you may be able to take a lower dose and still get the same results."
https://www.healthline.com/health/sublingual-and-buccal-medication-administration
"The absorption of the drug through the sublingual route is 3x –10x greater than the [traditional] oral route and is only surpassed by hypodermic injection. Sublingually absorbed nutrition avoids exposure to the gastric system and liver, meaning direct nutritional benefits."
https://innovareacademics.in/journal/ijpps/Vol3Suppl2/1092.pdf
"Intraoral delivery of dietary supplements and nutraceuticals through the mucosal linings of the oral cavity offers distinct advantages over peroral delivery through the GI tract. Supplements taken up by the oral mucosa directly enter the systemic circulation from the jugular vein, thus avoiding passage through the liver where they may undergo undesirable metabolism (1st pass liver effects). Other tangible benefits include increased absorption, faster onset of actions and greater bioavailability. Furthermore, intraoral delivery does not require swallowing and does not produce gastrointestinal irritation."
Advantages of intraoral delivery include:
- Increased bioavailability
- Rapid absorption and onset of actions
- Avoids presystemic elimination in the GI tract
- Avoids first-pass effect of the liver
- Avoids exposure to a hostile GI environment
https://life-enhancement.com/pages/intraoral-delivery-is-a-better-route
First Pass Metabolism
"The first pass effect is a phenomenon in which a drug gets metabolized at a specific location in the body that results in a reduced concentration of the active drug upon reaching its site of action or the systemic circulation. The first pass effect is often associated with the liver, as this is a major site of drug metabolism."
https://www.ncbi.nlm.nih.gov/books/NBK551679/
"First-pass metabolism: a process in which a drug administered by mouth is absorbed from the gastrointestinal tract and transported via the portal vein to the liver, where it is metabolized. As a result, in some cases only a small proportion of the active drug reaches the systemic circulation and its intended target tissue. First-pass metabolism can be bypassed by giving the drug via sublingual or buccal routes."
https://www.slideshare.net/BUDDHABHUSHAN0/first-pass-metabolism-buddhabhushan-dongre
"Two ways to bypass first pass metabolism involve giving the drug by sublingual and buccal routes.
In buccal administration the drug is placed between the teeth and the mucous membrane of the cheek. Sublingual and buccal methods both avoid destruction by the GI fluids and first pass effect of the liver."
https://www.nottingham.ac.uk/nmp/sonet/rlos/bioproc/metabolism/02.html
"To be absorbed, a drug [swallowed] orally must survive encounters with low pH and numerous GI secretions, including potentially degrading enzymes. Absorption of oral [swallowed] drugs involves transport across membranes of the epithelial cells in the GI tract. The stomach has a relatively large epithelial surface, but its thick mucus layer and short transit time limit absorption. Absorption is affected by:"
- Differences in luminal pH along the GI tract
- Surface area per luminal volume
- Blood perfusion
- Presence of bile and mucus
- The nature of epithelial membranes
https://www.merckmanuals.com/professional/clinical-pharmacology/pharmacokinetics/drug-absorption
Bioavailability
"A common belief regarding bioavailability of dietary supplements is that they have to be in solution to be absorbed in the body. However, the veracity of this axiom with regard to commercially available supplements was recently called into question."
https://academic.oup.com/jn/article/131/4/1349S/4686865
"Ingested fluids are not easily assimilated into the body. They are initially stored in the stomach, and there is little net absorption of water or solute across the gastric mucosa."
https://academic.oup.com/nutritionreviews/article/73/suppl_2/57/1930269
"When we take nutrition orally in tablet or capsule form, the digestive system has to work hard to digest them. Oftentimes, the stomach breaks vitamins down before they can make it to the liver for filtration and then enter the bloodstream."
Liver Damage -- from traditional supplements
"Many adverse effects are linked to consuming dietary supplement products, including hepatoxicity, or chemically induced liver damage, according to the Drug-Induced Liver Injury Network. A recent paper from two University of Michigan hepatologists highlights the liver dangers associated with consuming some dietary supplements designed to build muscle or lose weight."
"In about half the cases involving bodybuilding supplements and 41% of cases involving weight loss supplements, researchers concluded that the products definitely were the cause of drug-induced liver injury. These people weren’t taking any other medications."
"Herbal and Dietary supplements (HDS) are used increasingly in both the United States and worldwide and HDS induced liver injury in the U.S. has increased proportionally. The major implicated agents include multi-ingredient nutritional supplements (MINS). The majority of HDS-associated liver injury are due to MINS."
https://pubmed.ncbi.nlm.nih.gov/27677775/
"Many herbal remedies and dietary supplements can harm the liver, including some that you can easily buy online or over-the-counter in drug or health food stores. The studies also found that injuries linked to those supplements are rising fast, jumping from just 7% of all drug-induced liver injuries in 2004 to about 20% in 2014."
https://www.consumerreports.org/health/liver-damage-from-supplements-is-on-the-rise/